[61]

Translational Medicine: From Ground-Based Studies of Traumatic Injuries to Astronaut Health and Earth Benefits.   Charles E. Wade, US Army Institute of Surgical Research, Fort Sam  Houston TX 78234

   Traumatic injuries are an everyday occurrence, from the minor scratch to  the massive injuries of an auto accident. Based on this information NASA  has prepared for a range of contingencies to care for an injured astronaut. These preparations have been based upon clinical incidences in environmental corollaries such as Arctic habitats. However, information is needed as to the effect of acclimation to the space environment on responses to injury, subsequent treatment and rehabilitation. Deconditioning of a subject leads to significant alterations in the responses hemorrhage, susceptibility to infection, and healing. The treatment of the injured subject may have to be altered to compensate for the effects of acclimation in light of these findings. Furthermore, upon return to Earth's gravity therapeutic interventions, such as administration of anesthetics, may have to be adjusted. The response of patients to the deconditioning of acute bedrest associated with the care of traumatic injuries provides insights to care of an injured astronaut. In order to assure mission success of long duration space flights the care of even minor injuries should be extensively evaluated.